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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
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Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Classifying Matter by State02:49

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Chemistry is the study of matter and the changes it undergoes. Matter is anything that has mass and occupies space. Matter is all around us; the air, water, soil, mountains, even our bodies are all examples of matter. Matter is divided into three states — solid, liquid, and gas — that are commonly found on earth. The fourth state of matter, plasma, occurs naturally in the interiors of stars. 
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Classifying Matter by Composition03:35

Classifying Matter by Composition

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Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures. 
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated. 
A mixture is composed of two or...
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Physical and Chemical Properties of Matter02:57

Physical and Chemical Properties of Matter

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The characteristics that enable us to distinguish one substance from another are called properties.
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Related Experiment Video

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Induction of an Inflammatory Response in Primary Hepatocyte Cultures from Mice
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Systemic inflammatory response after hyperthermic intraperitoneal chemotherapy (HIPEC): The perfusion protocol

Lilian Roth1, Dilmurodjon Eshmuminov1, Felix Laminger2

  • 1Surgical Oncology Research Laboratory, Department of Surgery & Transplantation, University Hospital of Zurich, Zurich, Switzerland.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|April 8, 2019
PubMed
Summary

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) protocols impact postoperative inflammatory responses. Longer HIPEC durations (90 min) with specific drugs trigger a secondary inflammatory peak, unlike shorter 30-min treatments.

Keywords:
Cytoreductive surgery (CRS)Hyperthermic intraperitoneal chemotherapy (HIPEC)Peritoneal metastasis

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Peritoneal Metastasis Treatment

Background:

  • Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) is established for peritoneal metastasis.
  • The underlying pathophysiology of HIPEC is not fully understood, with varied treatment protocols in use.
  • This study investigates the postoperative systemic inflammatory reaction differences across HIPEC regimens.

Purpose of the Study:

  • To elucidate the impact of different HIPEC protocols on postoperative systemic inflammation.
  • To compare inflammatory markers following varying perfusion times and chemotherapeutic agents in HIPEC.

Main Methods:

  • Three HIPEC protocols were employed: mitomycinC/doxorubicin (90 min), cisplatin (90 min), and oxaliplatin (30 min).
  • Systemic inflammatory markers including C-reactive protein (CRP), white blood cells (WBC), pancreatic stone protein (PSP), and 16s rDNA were serially measured.
  • Data from 140 patients across two European centers were analyzed.

Main Results:

  • A secondary inflammatory peak (CRP, PSP) was observed after 90-min HIPEC with mitomycinC/doxorubicin or cisplatin, but not with 30-min oxaliplatin.
  • Postoperative serum 16s rDNA levels were 2.1 times higher in patients undergoing 90-min HIPEC compared to 30-min oxaliplatin.
  • These inflammatory changes were noted in patients without postoperative complications.

Conclusions:

  • A distinct secondary inflammatory response occurs after 90-min HIPEC using mitomycinC/doxorubicin or cisplatin.
  • Short-course 30-min HIPEC with oxaliplatin did not elicit this secondary inflammatory reaction.
  • Understanding these protocol-dependent acute-phase protein dynamics is crucial for managing patients post-HIPEC.