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Renal resistive index as a predictive factor of delayed graft function: A meta-analysis
Ioannis Bellos1, Despina N Perrea1, Konstantinos Kontzoglou2
1Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, Athens University Medical School, National and Kapodistrian University of Athens, Greece.
Transplantation Reviews (Orlando, Fla.)
|April 8, 2019
Summary
Elevated renal resistive index (RRI) after kidney transplantation is linked to a higher risk of delayed graft function (DGF). This meta-analysis highlights RRI
Area of Science:
- Nephrology
- Transplant Surgery
- Medical Imaging
Background:
- Delayed graft function (DGF) is a significant complication following kidney transplantation.
- DGF is associated with increased short- and long-term morbidity in kidney recipients.
Purpose of the Study:
- To evaluate the predictive efficacy of renal resistive index (RRI) measurements for DGF post-kidney transplantation.
- To assess the role of RRI in the early post-transplant period.
Main Methods:
- Systematic literature search across multiple databases (Medline, Scopus, CENTRAL, ClinicalTrials.gov, Google Scholar).
- Meta-analysis of 14 studies involving 2741 kidney recipients.
- Statistical analysis using Review Manager 5.3, R 3.4.3, and Open Meta-Analyst.
Main Results:
- Higher RRI values were significantly associated with DGF (Odds Ratio: 1.96).
- RRI was significantly higher in patients with DGF compared to those with slow or immediate graft function.
- Pooled sensitivity for DGF detection was 47.2%, specificity 69.3%, with an AUC of 0.613.
Conclusions:
- Elevated RRI early after kidney transplantation shows promise in predicting DGF.
- Further large-scale studies are needed to determine optimal RRI cut-off values and integrate it into predictive models.
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