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Predicting Catalyst Extrudate Breakage Based on the Modulus of Rupture

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Mannich base Cu(II) complexes as biomimetic oxidative catalyst.

Bidyut Kumar Kundu¹, Rishi Ranjan¹, Attreyee Mukherjee²

¹Discipline of Chemistry, School of Basic Sciences, Indian Institute of Technology Indore, Khandwa Road, Simrol, Indore 453552, India.

Journal of Inorganic Biochemistry

|April 8, 2019

Summary

This summary is machine-generated.

New copper complexes mimic galactose oxidase (GOase) and catechol oxidase (COase) enzymes. Complex 1, with a mono-ligand environment, shows superior catalytic activity in mimicking both GOase and COase reactions.

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Area of Science:

Bioinorganic Chemistry
Catalysis
Coordination Chemistry

Background:

Copper metalloenzymes like Galactose Oxidase (GOase) and catechol oxidase (COase) play crucial roles in biological oxidation reactions.
Understanding the structure-activity relationship of copper active sites is key to designing synthetic mimics.
Mononuclear copper complexes offer a platform to model the functionalities of these enzymes.

Purpose of the Study:

To synthesize and characterize novel mononuclear copper(II) complexes.
To investigate the catalytic activities of these complexes in mimicking GOase and COase.
To elucidate the mechanistic aspects and identify reactive intermediates during catalysis.

Main Methods:

Synthesis of mononuclear copper(II) complexes [CuL(OAc)] (1) and [CuL2] (2).
Structural elucidation using X-ray crystallography.
Characterization by EPR, GC-MS, HPLC, and ESI-MS.
Catalytic studies for GOase and COase mimicking reactions.

Main Results:

Complexes 1 and 2 successfully mimicked the catalytic activities of GOase and COase.
Complex 1 demonstrated higher catalytic efficiency (kcat, TON) in COase mimicking oxidation of 3,5-DTBC to 3,5-DTBQ compared to complex 2.
Benzyl alcohol oxidation to benzaldehyde was significant with complex 1 in the presence of a strong base.
Hydrogen peroxide (H2O2) was identified as a byproduct, indicating reactive oxygen species generation.

Conclusions:

Mononuclear copper(II) complexes can effectively mimic the catalytic functions of GOase and COase.
The coordination environment around the copper center significantly influences catalytic activity, with mono-ligand coordination (Complex 1) being superior.
These findings contribute to the development of artificial metalloenzymes for oxidation catalysis.