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A Technique to Screen American Beech for Resistance to the Beech Scale Insect Cryptococcus fagisuga Lind.
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Deciphering mechanisms of response and resistance in large-scale mouse cancer screens

Anirudh Prahallad1, Michael Rugaard Jensen1, Emilie Anne Chapeau1

  • 1Oncology Disease Area, Novartis Institutes for BioMedical Research, Basel, Switzerland.

Current Opinion in Genetics & Development
|April 8, 2019
PubMed

Insights

Acquired resistance limits cancer treatment success. This review explores how large-scale screens in preclinical models identify mechanisms of drug resistance and guide combination therapies for better patient outcomes.

Area of Science:

  • Oncology
  • Cancer Research
  • Pharmacology

Background:

  • Acquired resistance to cancer therapeutics is a significant clinical challenge.
  • Tumor genetic alterations and microenvironment modulation contribute to treatment failure.
  • Understanding resistance mechanisms is crucial for developing durable cancer treatments.

Purpose of the Study:

  • To review large-scale in vivo screening strategies for elucidating acquired drug resistance.
  • To identify novel combination therapies based on resistance mechanisms.
  • To inform the design of clinical trials for improved cancer treatment.

Main Methods:

  • Review of large-scale in vivo screens in preclinical cancer models.
  • Analysis of genetic and pharmacological agents used in resistance studies.
  • Evaluation of identified resistance mechanisms and potential combination strategies.

Main Results:

  • In vivo screens effectively identify key drivers of acquired drug resistance.
  • Understanding tumor environment modulation aids in predicting resistance.
  • Data from preclinical models can guide the selection of effective combination therapies.

Conclusions:

  • Large-scale in vivo screens are powerful tools for dissecting cancer drug resistance.
  • Elucidating resistance mechanisms is essential for developing next-generation cancer therapies.
  • Findings support the clinical testing of novel combination strategies for durable cancer treatment.

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