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DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
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Switchable length nanotubes from a self-assembling pH and thermosensitive linear l,d-peptide-polymer conjugate.

Serena De Santis1, Federica Novelli1, Fabio Sciubba1

  • 1Dipartimento di Chimica, Sapienza Università di Roma, P.le A. Moro, 5, I-00185 Rome, Italy.

Journal of Colloid and Interface Science
|April 8, 2019
PubMed
Summary

This study reports novel pH and thermosensitive peptide-polymer nanotubes. These single-channel nanotubes exhibit tunable length from nanometers to micrometers, offering versatile applications.

Keywords:
Linear l,d-octapeptideNanotubesPoly(dimethylamino ethyl methacrylate) (PDMAEMA)Self–assemblyThermosensitivepH-sensitive

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Linear peptides with alternating enantiomeric sequences can self-assemble into nanotubes.
  • Stimuli-responsive polymers offer dynamic control over material properties.
  • Combining peptides and polymers can lead to advanced functional nanomaterials.

Purpose of the Study:

  • To synthesize and characterize a novel pH and thermosensitive linear octapeptide-poly(dimethylamino ethyl methacrylate) conjugate.
  • To investigate the self-assembly behavior and stimuli-responsive properties of the peptide-polymer conjugate.
  • To explore the potential for controlling nanotube dimensions via pH and temperature.

Main Methods:

  • Synthesis of a linear (l-Val-d-Val)4 octapeptide.
  • Atom transfer radical polymerization (ATRP) to obtain poly(dimethylamino ethyl methacrylate) (PDMAEMA).
  • Click-chemistry conjugation of the peptide and polymer.
  • Characterization of nanotube formation and dimensions using microscopy and dynamic light scattering.

Main Results:

  • The (l-Val-d-Val)4-PDMAEMA conjugate self-assembles into single-channel nanotubes with lengths ranging from 0.2-1.5 μm.
  • Nanotube length can be reversibly modulated from hundreds of nanometers to several micrometers by adjusting pH and temperature (above the lower critical solution temperature of PDMAEMA).
  • Sonication reduces nanotube length to 0.2-0.5 μm, yielding low polydispersity structures.

Conclusions:

  • This work presents the first example of thermosensitive peptide-polymer single-channel nanotubes with externally controllable length.
  • The developed nanotubes demonstrate reversible length changes in response to pH and temperature.
  • The ability to tune nanotube dimensions offers significant potential for applications in drug delivery, sensing, and nanoreactors.