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Updated: Jan 26, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
Published on: August 21, 2017
Paraneoplastic neuromyelitis optica and ovarian teratoma: A case series
Raphaël Bernard-Valnet1, Alvaro Cobo-Calvo2, Aurore Siegfried3
1Center for pathophysiology Toulouse Purpan, INSERM U1043, CNRS 5282, Université Toulouse III, 31024 Toulouse, France; CRC-SEP, Pôle Neurosciences, CHU de Toulouse, 31059 Toulouse, France; Neurosciences and Medicine Departments, Centre hospitalier universitaire vaudois (CHUV), 1011 Lausanne, Switzerland.
Abstract:
Neuromyelitis optica spectrum disorder (NMOSD) is a rare inflammatory disease of the central nervous system, characterized by the presence of auto-antibodies directed against aquaporin-4 (AQP4) expressed on astrocyte end-feet. Despite NMOSD does not primarily belong to the spectrum of paraneoplastic neurological syndromes, rare cases of association with neoplasia have been outlined. Here, we report the association of NMOSD with ovarian teratoma in 3 cases. Pathological analysis of teratomas revealed glial component strongly expressing AQP4 and closely localized to immune infiltrates. Our series highlight the rare association of teratoma with NMOSD and the possible paraneoplastic mechanism.
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