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Updated: Jan 26, 2026
09:27
Wind Tunnel Experiments to Study Chaparral Crown Fires
Published on: November 14, 2017
10.1K
Summary
Tocilizumab effectively terminated status epilepticus in most patients with new-onset refractory status epilepticus (NORSE). However, severe infections occurred in two patients, warranting further investigation into tocilizumab
Area of Science:
- Neurology
- Immunology
Background:
- New-onset refractory status epilepticus (NORSE) presents a significant therapeutic challenge.
- Conventional immunotherapy may not be effective in all NORSE cases.
Purpose of the Study:
- To evaluate the efficacy and safety of tocilizumab, an interleukin-6 receptor inhibitor, for treating NORSE.
- To assess tocilizumab's potential in patients refractory to other treatments.
Main Methods:
- A study involving 7 patients diagnosed with NORSE.
- Tocilizumab was administered to patients refractory to conventional immunotherapy (rituximab or no rituximab).
Main Results:
- Status epilepticus (SE) resolved in 6 out of 7 patients after 1-2 doses of tocilizumab.
- SE recurrence was not observed during the follow-up period in treated patients.
- Two patients experienced severe adverse events, specifically infections, during tocilizumab therapy.
Conclusions:
- Tocilizumab shows therapeutic potential in treating NORSE, particularly in refractory cases.
- Further prospective controlled studies are necessary to confirm the efficacy and safety profile of tocilizumab for NORSE.
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