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Complement receptor-associated CD163+/CD18+/CD11c+/CD206-/CD209- expression profile in chronic histiocytic

Kais Hussein1, Angelika Stucki-Koch1, Annette M Müller2

  • 1Institute of Pathology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Placenta
|April 9, 2019
PubMed

Insights

Chronic histiocytic intervillositis of unknown etiology (CIUE) involves abnormal accumulation of CD163+ histiocytes in the placenta. These cells over-express CD11c/CD18 and down-regulate CD206/CD209, potentially linked to complement activation.

Area of Science:

  • Reproductive immunology
  • Perinatal pathology
  • Histiocytic cell biology

Background:

  • Chronic histiocytic intervillositis of unknown etiology (CIUE) is a severe placental lesion linked to adverse pregnancy outcomes.
  • CIUE presents a high recurrence risk (67-100%) in subsequent pregnancies.
  • The immunophenotype of intervillous histiocytes in CIUE remains poorly understood.

Purpose of the Study:

  • To investigate the expression profile of histiocytic markers in placental intervillous cells in CIUE.
  • To differentiate the immunophenotype of intervillous histiocytes from decidual and Hofbauer cells in CIUE.

Main Methods:

  • Immunohistochemistry was employed to analyze 5-22 markers.
  • A total of 41 placenta samples were evaluated.
  • Decidual, villous, and intervillous histiocytic cells were assessed.

Main Results:

  • Intervillous CD163+ histiocytes in CIUE over-expressed CD11c/CD18 and down-regulated CD206/CD209.
  • CD163+ decidual and Hofbauer cells exhibited low CD11c/CD18 and higher CD206/CD209 expression.
  • CD163 expression suggests M2-like polarization of these histiocytes.

Conclusions:

  • The distinct marker expression profile of intervillous histiocytes in CIUE may indicate a specific role in the pathology.
  • Over-expression of CD11c/CD18, components of complement receptor 4, suggests a potential complement-mediated mechanism in CIUE pathogenesis.
Abstract

Keywords:
CD11cCD163CD18Chronic histiocytic intervillositisPlacenta

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