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Heavy Chain Fibrillary Glomerulonephritis: A Case Report
Samih H Nasr1, Christophe Sirac2, Frank Bridoux3
1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
A new kidney disease, heavy chain fibrillary glomerulonephritis, is caused by immunoglobulin heavy chain deposits in patients with monoclonal gammopathy. This DNAJB9-negative condition can lead to kidney failure and recurrence after transplantation.
Area of Science:
- Nephrology
- Immunopathology
- Oncology
Background:
- Heavy chain amyloidosis and heavy chain deposition disease are kidney diseases from truncated immunoglobulin heavy chains.
- Fibrillary glomerulonephritis (FGN) typically involves DNAJB9 (DnaJ heat shock protein family [Hsp40] member B9) and immunoglobulin G (IgG) deposition.
- Monoclonal gammopathy (MG) is associated with various kidney diseases.
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