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Possible Dose-Response Relationship in Palliative Radiotherapy for Non-bone Painful Lesions.
T Saito1, E Tomitaka2, R Toya3
1Department of Radiation Oncology, Kumamoto University Hospital, Kumamoto, Japan; Department of Radiation Oncology, Hitoyoshi Medical Center, Hitoyoshi, Japan.
Clinical Oncology (Royal College of Radiologists (Great Britain))
|April 9, 2019
Summary
Higher radiation doses may improve pain relief for non-bone tumors, but more research is needed. This study explored the dose-response relationship in palliative radiotherapy for painful lesions, excluding bone metastases.
Area of Science:
- Oncology
- Radiotherapy
- Pain Management
Background:
- Total radiation dose does not predict pain response in bone metastases radiotherapy.
- The dose-response relationship for non-bone painful tumors is unknown.
- Palliative radiotherapy is used for painful lesions.
Purpose of the Study:
- To determine if higher total radiation dose predicts a better pain response rate.
- To investigate the dose-response relationship in palliative radiotherapy for non-bone painful lesions.
Main Methods:
- Secondary analysis of a prospective observational study.
- Collected Brief Pain Inventory data at baseline and 1, 2, 3 months post-radiotherapy.
- Used Fine-Gray model with competing risks for analysis.
Main Results:
- Total radiation dose was an independent predictor of pain response in non-bone lesions (38% of patients).
- No significant differences in pain response rates between bone and non-bone lesions.
- The finding of dose-response was not robust to sensitivity analysis.
Conclusions:
- Higher total radiation dose appeared associated with improved pain response in non-bone lesions.
- This association was not robust, indicating a need for further investigation.
- Clinical trials are recommended to explore the dose-response relationship in these tumors.
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