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ZEBs: Novel Players in Immune Cell Development and Function.

Charlotte L Scott1, Kyla D Omilusik2

  • 1Vlaams Instituut voor Biotechnologie (VIB) Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Institute of Infection, Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, UK.

Trends in Immunology
|April 9, 2019
PubMed
Summary
This summary is machine-generated.

Zinc-finger E homeobox-binding transcription factors (ZEBs) regulate immune cell function. This review explores ZEBs

Keywords:
DevelopmentFunctionLymphoidMyeloidZEB1ZEB2

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Area of Science:

  • Immunology
  • Molecular Biology
  • Transcription Factors

Background:

  • Zinc-finger E homeobox-binding transcription factors (ZEB1 and ZEB2) are primarily known for their role in epithelial to mesenchymal transition.
  • Recent research reveals ZEBs are also expressed in various immune cells, including myeloid (dendritic cells, macrophages, monocytes) and lymphoid (B, T, and NK cells) lineages.

Purpose of the Study:

  • To review the current understanding of ZEB regulation in immune cell lineages, with a focus on mouse models.
  • To identify existing gaps in knowledge regarding ZEBs' function in immunity.
  • To propose future research directions in the field.

Main Methods:

  • Literature review of studies on ZEB1 and ZEB2 expression and function in immune cells.
  • Analysis of data primarily from mouse models.
  • Synthesis of current knowledge and identification of research gaps.

Main Results:

  • ZEBs play crucial roles in the differentiation, maintenance, and function of diverse immune cell types.
  • ZEB regulation is complex and varies across different immune cell lineages.
  • Significant gaps remain in understanding the precise mechanisms and in vivo functions of ZEBs in immunity.

Conclusions:

  • ZEBs are critical regulators of immune cell biology beyond their established roles in epithelial to mesenchymal transition.
  • Further research is needed to fully elucidate the functions and regulatory networks of ZEBs in the immune system, particularly in non-mouse models.
  • Future studies should focus on addressing the identified knowledge gaps to advance our understanding of immune cell regulation.