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Assessment of Concentrations of Four Phenothiazine Antipsychotics in Serum and Whole Blood Using Different
Takeshi Saito1, Akira Namera2, Tomoatsu Tsuji1
1Department of Emergency and Critical Care Medicine, Tokai University School of Medicine.
Abstract:
This study attempted to determine the phenothiazine antipsychotics concentration in serum and whole blood samples using various diatomaceous earth-based solid-phase columns and elution solvents and subsequently evaluate their efficiency. Phenothiazine antipsychotics concentrations of 5 - 2000 ng/mL were extracted from serum and whole blood using each column. All compounds were analyzed using liquid chromatography-tandem mass spectrometry. Phenothiazine antipsychotics extraction in serum and whole blood using diatomaceous earth-based solid-phase columns seemed to have an affinity with the elution solvent.
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