Partial Fanconi syndrome induced by ifosfamide
Muhammad Ajmal Panezai1, Charles Owen1, Harold M Szerlip1
1Division of Nephrology, Baylor University Medical CenterDallasTexas.
Proceedings (Baylor University. Medical Center)
|April 9, 2019
Summary
Ifosfamide chemotherapy can cause kidney damage, leading to Fanconi syndrome. This case report details a patient with Ewing sarcoma who developed this condition, exploring its underlying mechanism.
Area of Science:
- Nephrology
- Oncology
- Pharmacology
Background:
- Ifosfamide is a chemotherapy agent used to treat various cancers.
- Ifosfamide-induced nephropathy presents as a spectrum, ranging from hyperaminoaciduria to Fanconi syndrome.
- Fanconi syndrome is a generalized proximal tubular dysfunction.
Observation:
- A patient with metastatic progressive Ewing sarcoma developed ifosfamide-induced partial Fanconi syndrome.
- The patient presented with symptoms indicative of proximal tubular dysfunction.
Findings:
- The case highlights the potential for ifosfamide to cause significant renal toxicity.
- A hypothesis regarding the mechanism of ifosfamide-induced partial Fanconi syndrome is proposed.
Implications:
- Understanding the mechanism of ifosfamide nephrotoxicity is crucial for patient management.
- This case may inform strategies to mitigate or treat chemotherapy-induced kidney damage.
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