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Updated: Jan 26, 2026

Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus
Published on: October 1, 2015
Long-term antiviral hepatitis C treatment associated with Rods and Ring Cytoplasmic antibodies
Vasile Feldrihan1, Andreea Benea2, Monica Lia Junie3
1Functional Biosciences, Immunology and Allergy Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Aim:
Clinical description of a patient diagnosed with chronic hepatitis C virus infection, which associated a rare anti-cytoplasmic pattern, known as "Rods and Ring".
Method:
Clinical case report.
Results:
A 76-year old female patient with chronic hepatitis C virus infection under treatment for several months with pegylated Interferon-Ribavirin (started eight months ago) presented for clinical and biological evaluation of the therapeutic response.
Conclusion:
This is the first reported clinical case of a patient with cytoplasmic filamentous rods and rings autoantibodies associated with chronic hepatis C from the Clinical Hospital IRGH Prof. Dr. O. Fodor Cluj-Napoca, Romania. The presence of these antibodies appears to be triggered by antiviral therapy. Although these are newly identified antibodies, they could be used as serological markers for detecting patients at risk of developing associated autoimmune pathologies or nonresponders to the antiviral therapy. Likewise, their detection could identify patients with occult hepatitis C infection.
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