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Updated: Jan 26, 2026

Perspectives on Neuroscience
Published on: July 31, 2007
IL-17 inhibition in axial spondyloarthritis: current and future perspectives
Murat Torgutalp1,2, Denis Poddubnyy2,3
1a Division of Rheumatology, Department of Internal Medicine , Ankara University Faculty of Medicine , Ankara , Turkey.
Introduction:
Interleukin (IL)-17 is a proinflammatory cytokine considered to play a significant role in the immunopathogenesis of ankylosing spondylitis (AS)/axial spondyloarthritis (axSpA) as well as of other spondyloarthritides. There is a number of substances targeting IL-17, which are at different stages of development in the axSpA indication.
Areas Covered:
This review summarizes the current evidence on the role of IL-17 in the pathophysiology of axSpA and provided a comprehensive review of clinical and radiographic outcomes as well as of safety data from studies with IL-17A inhibitors secukinumab and ixekizumab. Ongoing studies on other IL-17 inhibitors (bimekizumab, brodalumab and BCD-085) that are being developed are also summarized.
Expert Opinion:
The development of the IL-17 inhibitors has expanded AS treatment with effective options and confirmed the pathophysiological role of IL-17 in axSpA. IL-17 inhibition showed sufficient efficacy against signs and symptoms of the disease even after the failure of tumor necrosis factor inhibitors, being at the same time reasonably safe.
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