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Related Experiment Video

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Author Spotlight: Exploring Dynamic Neural Changes Associated with Religious Chanting
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Reward Processing in Adolescent Depression Across Neuroimaging Modalities.

Georgia O'Callaghan1, Argyris Stringaris1

  • 1Mood Brain & Behavior Unit, Emotion & Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

Zeitschrift Fur Kinder- Und Jugendpsychiatrie Und Psychotherapie
|April 9, 2019
PubMed
Summary

Adolescent depression is linked to altered reward processing, showing reduced brain responses to rewards and blunted neural signals. These neural deficits may predict future depressive symptom onset in young people.

Keywords:
Abgeschwächte FRN Potentiale (EEG)BelohnungsverarbeitungDepression bei JugendlichenReduzierte striatale Reaktionen (MRT)adolescent depressionblunted feedback-related negativity (EEG)reduced striatal responses (MRI)reviewreward processingÜbersicht

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Developmental Psychology

Background:

  • Depressive symptoms are linked to abnormal neural reward processing.
  • Evidence in adolescent depression is not yet consolidated across neuroimaging modalities.
  • Understanding these deficits is crucial for targeted adolescent depression treatments.

Purpose of the Study:

  • To review and consolidate neuroimaging evidence of reward processing deficits in adolescent depression.
  • To integrate findings from functional magnetic resonance imaging (fMRI) and electroencephalography (EEG).
  • To explore the predictive value of these deficits for future depressive symptom onset.

Main Methods:

  • Systematic review of neuroimaging studies (fMRI, EEG) in adolescent depression.
  • Analysis of neural responses during reward anticipation and receipt.
  • Examination of feedback-related negativity (FRN) potentials.

Main Results:

  • Consistent evidence of reduced striatal responses to rewards in adolescents with depression.
  • Blunted feedback-related negativity (FRN) potentials observed in adolescent depression.
  • These neural deficits were also found to predict future depressive symptom onset in longitudinal studies.

Conclusions:

  • Adolescent depression is characterized by significant reward processing abnormalities.
  • These neural deficits are present in currently depressed adolescents and predictive of future onset.
  • Further research can inform more effective treatments for adolescent depression.