Emerging Trends in Information-Driven Engineering of Complex Biological Systems

Area of Science:

• Biomaterials Science
• Synthetic Biology
• Tissue Engineering

Background:

• Synthetic biological systems are crucial for in vivo tissue engineering and in vitro microengineered devices.
• Advances in bioinspired materials, biological tools, and computational methods are driving progress.
• The omics era necessitates integrating multi-scale biological information for advanced designs.

Purpose of the Study:

• To discuss trends in combining multiscale processes for next-generation biomaterial design.
• To review micro- and biofabrication techniques for hierarchical control.
• To highlight emerging polymer candidates for these technologies.

Main Methods:

• Review of current literature on multiscale process integration in biomaterials.
• Analysis of micro- and biofabrication techniques enabling hierarchical control.
• Identification of key polymer candidates for advanced tissue engineering.

Main Results:

• Successful microprocessing pipelines require integration of hierarchical information for functional tissue equivalents.
• Multiscale approaches are essential for designing sophisticated biomaterials.
• Emerging polymers show promise for advanced biofabrication.

Conclusions:

• Combining multiscale processes is vital for the future of biomaterials and tissue engineering.
• Hierarchical control through advanced fabrication techniques is critical.
• Interdisciplinary approaches combining biology, materials science, and computation are key.