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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Two New Prenylated Indole Diterpenoids from Tolypocladium sp. and Their Antimicrobial Activities
Lu-Lin Xu1,2, Xue-Jiao Pang1,2, Qiong Shi2
1School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, P. R. China.
Abstract:
Two new prenylated indole diterpenoids, tolypocladins K and L (1 and 2), together with a known analog terpendole L (3), were isolated from the solid fermentation culture of a mine soil-derived fungus Tolypocladium sp. XL115. Their structures and relative configurations were determined by comprehensive spectroscopic data analysis, as well as by comparison of their NMR data with those related known compounds. Compound 3 exhibited remarkable antibacterial activity against Micrococcus luteus with an MIC value of 6.25 μg/mL, and compounds 1 and 3 displayed moderate antifungal activity selectively against tested strains with MIC values of 25-50 μg/mL.
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