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Updated: Jan 26, 2026

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
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Intracellular and Cellular Detection by SERS-Active Plasmonic Nanostructures.

Di Wu1,2, Yonghao Chen2, Shuai Hou2

  • 1Department of Chemistry, Zhejiang University, Hangzhou, 310028, P.R. China.

Chembiochem : a European Journal of Chemical Biology
|April 9, 2019
PubMed
Summary

Surface-enhanced Raman scattering (SERS) offers amplified detection for biochemical research. Recent advances in SERS nanostructures enable cellular detection and hold potential for future clinical diagnostics.

Keywords:
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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Nanotechnology

Background:

  • Surface-enhanced Raman scattering (SERS) provides highly sensitive molecular fingerprinting.
  • Multiplexed biodetection using SERS probes is a key area of interest.
  • SERS technology has significant potential in biochemical and biomedical applications.

Purpose of the Study:

  • To summarize recent progress in SERS-active plasmonic nanostructures for cellular and intracellular detection.
  • To highlight the development of nanosensors with tailored properties for molecular and pathological profiling.
  • To discuss future challenges for SERS in quantitative bioanalysis and clinical diagnostics.

Main Methods:

  • Development of SERS-active plasmonic nanostructures.
  • Design of nanosensors with multifunctional properties.
  • Application of SERS for cellular and intracellular detection.

Main Results:

  • Recent progress in SERS-active nanostructures for cellular detection is summarized.
  • Nanosensors with tailored plasmonic and multifunctional properties have been developed.
  • The potential for multiplexed biodetection using SERS is highlighted.

Conclusions:

  • SERS technology shows great promise for biochemical and biomedical research.
  • Tailored nanosensors are crucial for profiling molecular and pathological processes.
  • Further development is needed for routine quantitative bioanalysis and clinical diagnostics using SERS.