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The internal energy of a thermodynamic system is the sum of the kinetic and potential energies of all the molecules or entities in the system. The kinetic energy of an individual molecule includes contributions due to its rotation and vibration, as well as its translational energy. The potential energy is associated only with the interactions between one molecule and the other molecules of the system. Neither the system's location nor its motion is of any consequence as far as the internal...
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Related Experiment Video

Updated: Jan 26, 2026

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
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International consensus statement on endoscopic skull-base surgery: executive summary.

Eric W Wang1, Paul A Gardner1, Adam M Zanation2

  • 1Center for Cranial Base Surgery, Departments of Otolaryngology and Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.

International Forum of Allergy & Rhinology
|April 9, 2019
PubMed
Summary

Endoscopic skull-base surgery (ESBS) offers a multidisciplinary approach to complex conditions. The International Consensus Statement on Endoscopic Skull Base Surgery (ICAR:SB) provides evidence-based recommendations for ESBS, highlighting modest overall evidence levels.

Keywords:
CSF rhinorrheaangiofibromaclival chordomacraniopharyngiomaendoscopic endonasal approachendoscopic endonasal skull-base surgeryesthesioneuroblastomaevidence-based medicinemeningiomanasoseptal flap reconstructionolfactory neuroblastomapituitary adenomasquamous cell carcinoma

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Area of Science:

  • Skull Base Surgery
  • Neurosurgery
  • Otolaryngology

Background:

  • Endoscopic skull-base surgery (ESBS) is a rapidly advancing field requiring collaboration between otolaryngology-head and neck surgeons and neurosurgeons.
  • The growing body of literature on ESBS necessitates critical evaluation of its associated challenges and complications.
  • The International Consensus Statement on Endoscopic Skull Base Surgery (ICAR:SB) addresses this need through a comprehensive review.

Framework:

  • The ICAR:SB document systematically reviewed 98 topics in ESBS.
  • Evidence-based reviews with recommendations (EBRR) and evidence-based reviews (EBR) were developed where sufficient evidence existed.
  • An iterative review process ensured consensus on the findings.

Implementation:

  • This executive summary compiles EBR and EBRR findings from ICAR:SB.
  • Key areas covered include management of cerebrospinal fluid rhinorrhea, intradural tumors, sinonasal malignancies, and clival tumors.
  • Reconstruction techniques and complications associated with ESBS are also addressed.

Implications:

  • The ICAR:SB Executive Summary outlines evidence-based recommendations on the benefits, drawbacks, and challenges of ESBS.
  • The current level of evidence in ESBS is modest, indicating significant opportunities for future research.
  • Addressing these knowledge gaps is crucial for advancing the field of endoscopic skull base surgery.