Related Experiment Video

Updated: Jan 26, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

6.0K

Emerging microRNA biomarkers for colorectal cancer diagnosis and prognosis

Bing Chen1,2, Zijing Xia1,3, Ya-Nan Deng1

  • 11 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy , No. 17, 3rd Section of People's South Road, Chengdu 610041 , People's Republic of China.

Open Biology
|April 9, 2019
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in colorectal cancer (CRC) development. Extracellular miRNAs show promise as biomarkers for CRC diagnosis and prognosis, aided by improved analytical techniques.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small, non-coding RNAs regulating gene expression.
  • miRNAs play critical roles in colorectal cancer (CRC) development and progression.
  • miRNAs are emerging as potential biomarkers for cancer detection and management.

Purpose of the Study:

  • To review the current understanding of miRNA roles in CRC.
  • To highlight the advantages of using miRNAs as biomarkers for CRC.
  • To discuss the potential of extracellular miRNAs in CRC diagnosis and prognosis.

Main Methods:

  • Literature review of miRNA research in colorectal cancer.
  • Analysis of studies on oncogenic and tumor-suppressive roles of miRNAs.
  • Evaluation of advancements in miRNA detection technologies.

Main Results:

  • miRNAs are implicated in both the initiation and advancement of CRC.
  • miRNA biomarkers offer advantages for CRC diagnosis, treatment selection, and recurrence monitoring.
  • Extracellular miRNAs are increasingly recognized for their diagnostic and prognostic value in CRC.

Conclusions:

  • miRNAs are significant players in colorectal cancer pathogenesis.
  • miRNA-based biomarkers hold substantial promise for improving CRC patient outcomes.
  • Further research and technological advancements will enhance the clinical utility of extracellular miRNAs in CRC.
Keywords:
biomarkerscolorectal cancerdiagnosis and prognosismicroRNAs

More Related Videos

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing15:17

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

Published on: September 25, 2011

14.4K
Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma07:59

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma

Published on: September 3, 2021

7.0K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.1K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.9K
Emerging Adulthood01:27

Emerging Adulthood

Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
656
Nursing Diagnosis01:22

Nursing Diagnosis

Following assessment, a nursing diagnosis is the next step in the nursing process. It begins after the nurse has collected and recorded the patient data. The purpose of diagnosing is to identify how the client responds to actual or potential health processes, identify factors that bestow or that cause health problems, the etiologies, and identify resources or strengths the individual, group, or community can draw on to prevent or resolve problems.
The nursing diagnosis focuses on evidence-based...
3.8K
Introduction Cardiac Emergencies01:30

Introduction Cardiac Emergencies

Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
325
Documentation of Nursing Diagnosis01:10

Documentation of Nursing Diagnosis

The nurse documents nursing diagnoses and enters them into the patient record. The identified patient's nursing diagnosis is either written out with a plan of care or entered into the electronic health record.
In some settings, data-driven computerized decision support systems are in place, allowing for more accurate nursing diagnoses. The database within one of these systems includes diagnostic labels defining characteristics, activities, and indicators for nursing. A nurse enters...
1.7K