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FEATURES OF ENDOTHELIAL DYSFUNCTION IN ELDERLY PERSONS WITH CORONARY HEART DISEASE AND CONCOMITANT GASTROESOPHAGEAL

L Khomenko1, A Vnukova1, Y Dvoiashkina1

  • 1Kharkiv Medical Academy of Postgraduate Education, Department of Therapy, Rheumatology and Clinical Pharmacology, Ukraine.

Georgian Medical News
|April 9, 2019
PubMed

Insights

Elderly patients with both coronary artery disease (CAD) and gastroesophageal reflux disease (GERD) exhibit specific endothelial dysfunction. This dysfunction is a primary driver of GERD in patients with concurrent CAD.

Area of Science:

  • Cardiology
  • Gastroenterology
  • Vascular Biology

Background:

  • Comorbidity, the presence of multiple diseases, is a significant challenge in elderly patients.
  • Coronary artery disease (CAD) and gastroesophageal reflux disease (GERD) are highly prevalent globally and frequently coexist.
  • Endothelial dysfunction plays a crucial role in the pathophysiology of various cardiovascular and gastrointestinal conditions.

Purpose of the Study:

  • To investigate the specific features of endothelial dysfunction in elderly individuals diagnosed with both CAD and GERD.
  • To elucidate the role of endothelial dysfunction in the development and presentation of GERD in the context of CAD.

Main Methods:

  • Assessment of endothelial dysfunction markers, including stable nitric oxide metabolites and endothelin-1 levels.
  • Evaluation of regional blood flow in the celiac trunk.
  • Measurement of esophageal tissue resistance and lower esophageal sphincter function.

Main Results:

  • Endothelial dysfunction in elderly patients with concomitant CAD and GERD is characterized by reduced nitric oxide metabolites and elevated endothelin-1.
  • Disturbances in celiac trunk blood flow were observed, contributing to decreased esophageal tissue resistance and lower esophageal sphincter dysfunction.
  • Endothelial dysfunction appears to be a primary mechanism driving GERD development in patients with CAD.

Conclusions:

  • Endothelial dysfunction is a key factor in the pathogenesis of GERD among elderly patients with concurrent coronary artery disease.
  • In cases of isolated GERD, endothelial dysfunction is a secondary phenomenon that worsens the clinical presentation.

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