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Updated: Jan 26, 2026

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A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

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Immunogenicity and Safety of a Sabin Strain-Based Inactivated Polio Vaccine: A Phase 3 Clinical Trial

Yuemei Hu1, Jianfeng Wang2, Gang Zeng3

  • 1Department of Vaccine Evaluation, Nanjing.

The Journal of Infectious Diseases
|April 9, 2019
PubMed

Insights

The Sabin strain-based inactivated polio vaccine (sIPV) is as effective as the traditional IPV in infants. This study confirms sIPV

Area of Science:

  • Vaccinology
  • Pediatric Infectious Diseases
  • Public Health

Background:

  • Poliomyelitis eradication efforts are ongoing globally.
  • The Sabin strain-based inactivated polio vaccine (sIPV) is crucial for polio elimination in developing nations.

Purpose of the Study:

  • To evaluate the immunogenicity and safety of the sIPV compared to the conventional inactivated polio vaccine (IPV).

Main Methods:

  • A randomized, controlled, double-blinded, noninferiority trial involving 1200 infants aged 60-90 days.
  • Infants received three doses of either sIPV or IPV at 0, 30, and 60 days.
  • Immunogenicity (seroconversion rates) and safety (adverse events) were assessed.

Main Results:

  • sIPV demonstrated noninferior seroconversion rates for poliovirus types 1 (98.0% vs 94.1%) and 2 (94.8% vs 84.0%) compared to IPV (P < .01).
  • Seroconversion for type 3 was high in both groups (98.9% vs 97.7%).
  • Fever was more common in the sIPV group (61.6% vs 49.8%, P < .01), but overall safety was good.

Conclusions:

  • The sIPV exhibits an immunogenicity profile that is noninferior to the conventional IPV.
  • sIPV demonstrates a favorable safety profile, supporting its use in infant immunization programs.
Abstract

Keywords:
PoliovirusSabin straininactivated vaccinephase 3 trial

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