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Updated: Jan 26, 2026
04:09
Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
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Advancing pharmacotherapy for diabetic foot ulcers
Ioanna Eleftheriadou1, Anastasios Tentolouris1, Nikolaos Tentolouris1
1a Diabetes Centre, First Department of Propaedeutic Internal Medicine , Medical School, National and Kapodistrian University of Athens, Laiko General Hospital , Athens , Greece.
Expert Opinion on Pharmacotherapy
|April 9, 2019
Summary
Newer treatments for diabetic foot ulcers (DFUs) show promise. Advanced options like empagliflozin, liraglutide, and platelet-rich plasma (PRP) may improve outcomes for non-healing DFUs.
Area of Science:
- Diabetology
- Wound Healing
- Pharmacology
Background:
- Standard diabetic foot ulcer (DFU) treatments often yield unsatisfactory outcomes.
- Effective management requires addressing off-loading, debridement, infection, peripheral arterial disease (PAD), and glycemic control.
Purpose of the Study:
- To outline novel pharmacological agents for DFU management.
- To provide expert perspectives on future DFU treatment strategies.
Main Methods:
- Review of current literature on DFU management.
- Expert opinion on emerging therapies and future research directions.
Main Results:
- Empagliflozin and liraglutide are recommended for glycemic control in DFUs with PAD.
- Evolocumab may benefit DFUs with unmet cholesterol goals.
- Sucrose octasulfate dressings, becaplermin gel, and platelet-rich plasma (PRP) are potential advanced treatments.
Conclusions:
- High-quality evidence from RCTs is needed for new DFU guidelines.
- Further studies are warranted to develop treatment algorithms for refractory DFUs.
- Emerging therapies offer new hope for managing complex diabetic foot ulcers.
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