Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

1.2K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.2K
Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

2.9K
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
2.9K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.2K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.2K
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

1.5K
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
1.5K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

3.2K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.2K
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.8K
The pathophysiology of pneumonia involves the following steps:
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Eczematous component in psoriasis is possibly a negative prognostic factor for deucravacitinib treatment outcome.

Dermatology (Basel, Switzerland)·2026
Same author

Trust in skincare and topical therapies in atopic dermatitis or psoriasis: a German cross-sectional study.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

Insights into Api m 10-Isoforms and Splice Variants: More Than One Major IgE-Binding Epitope.

Clinical and translational allergy·2026
Same author

Treatment Preferences Among Systemic Therapy-Naïve Patients with Atopic Dermatitis or Psoriasis in Germany: A Multicentre Study.

Dermatology and therapy·2025
Same author

Anifrolumab has a direct immunoregulatory effect on inflamed keratinocytes: implications for the treatment of lupus erythematosus skin lesions.

Frontiers in immunology·2025
Same author

The respiratory allergy patient's healthcare journey: An international qualitative survey employing an ethnographic approach.

The World Allergy Organization journal·2025

Related Experiment Video

Updated: Jan 26, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

10.1K

Pathophysiology of atopic dermatitis.

William Grobe1, Thomas Bieber1, Natalija Novak1

  • 1Department of Dermatology and Allergology, Christine Kühne Center for Allergy Research and Education, Universität of Bonn, Bonn, Germany.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|April 9, 2019
PubMed
Summary

Atopic dermatitis (AD) research has revealed complex genetic and immune alterations. Recent advances are enabling precision medicine approaches for better diagnosis and treatment of this common inflammatory skin condition.

More Related Videos

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

25.0K
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.5K

Related Experiment Videos

Last Updated: Jan 26, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

10.1K
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

25.0K
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.5K

Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease affecting up to 30% of children and 1-10% of adults.
  • Numerous genetic and immune system alterations underlie AD, leading to diverse patient subgroups and disease manifestations.
  • Traditional AD treatments, especially for moderate-to-severe cases, were largely symptomatic and non-specific.

Purpose of the Study:

  • To review recent pathophysiological insights into atopic dermatitis.
  • To highlight how advanced research facilitates better patient subgroup characterization and understanding of disease variations.
  • To discuss the foundation for developing precision medicine in AD management.

Main Methods:

  • Literature review of recent pathophysiological and immunological studies on atopic dermatitis.
  • Analysis of genetic and immune alterations in different patient groups.
  • Examination of current and emerging therapeutic strategies, including biologics.

Main Results:

  • Identification of complex genetic and immune system alterations in AD.
  • Recognition of heterogeneity in disease manifestations, triggers, and severity.
  • Emergence of targeted therapies, such as biologics, for moderate-to-severe AD.

Conclusions:

  • Recent research provides deeper insights into AD pathophysiology.
  • Advances enable precise characterization of patient subgroups and disease phenotypes.
  • These findings pave the way for precision medicine approaches in atopic dermatitis treatment.