Related Experiment Videos
Haemostatic abnormalities in canine Cushing's syndrome
Research in Veterinary Science
|September 1, 1986
Summary
Canine Cushing's syndrome shows altered blood clotting factors, with some elevated and others normal. These changes do not indicate an increased risk of thrombosis in dogs with this condition.
Area of Science:
- Veterinary Medicine
- Haematology
- Endocrinology
Background:
- Canine Cushing's syndrome is a common endocrine disorder.
- Haemostatic abnormalities are often observed in affected dogs.
- The prothrombotic potential in these dogs requires further investigation.
Purpose of the Study:
- To evaluate specific haemostatic parameters in dogs with naturally occurring Cushing's syndrome.
- To determine if observed haemostatic changes are associated with an increased risk of thrombosis.
Main Methods:
- Evaluated 12 dogs with confirmed Cushing's syndrome.
- Measured plasma concentrations of coagulation factors (V, IX, X, VIII:C), fibrinogen, antithrombin III (ATIII), and plasminogen.
- Assessed for clinical evidence of thromboembolic complications.
Main Results:
- Significantly increased levels of factors V and X (P<0.01).
- Modestly increased fibrinogen concentration (P<0.05).
- Markedly elevated antithrombin III (ATIII) and plasminogen concentrations (P<0.001).
- Factors IX and VIII:C remained within the reference range.
- No thromboembolic complications were observed in the study population.
Conclusions:
- Haemostatic alterations in canine Cushing's syndrome include elevated procoagulant factors and significantly increased levels of ATIII and plasminogen.
- Despite these changes, the overall haemostatic profile does not suggest a hypercoagulable state.
- The findings indicate that haemostatic abnormalities in canine Cushing's syndrome may not predispose dogs to thrombosis.