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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Atherosclerosis III: Management01:26

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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The Extracellular Matrix01:42

The Extracellular Matrix

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The Extracellular Matrix01:29

The Extracellular Matrix

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In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

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Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
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Evaluation of the Storage Stability of Extracellular Vesicles
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Extracellular vesicles in atherosclerosis.

WenYi Deng1, TingTing Tang1, YangFeng Hou2

  • 1Pathophysiology Department, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, University of South China, Hengyang City, Hunan Province 421001, PR China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|April 9, 2019
PubMed
Summary
This summary is machine-generated.

Extracellular vesicles (EVs) in blood are linked to cardiovascular diseases and atherosclerosis. These vesicles play roles in inflammation and vascular remodeling, offering potential as biomarkers and therapeutic targets.

Keywords:
AtherosclerosisCardiovascular diseasesExosomesExtracellular vesiclesMicrovesicles

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Area of Science:

  • Cardiovascular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Extracellular vesicles (EVs) are present in human blood and their levels increase in inflammation-related cardiovascular diseases.
  • EVs are implicated in critical biological processes including inflammation, immunity, signal transduction, cell survival, apoptosis, angiogenesis, thrombosis, and autophagy.
  • These processes are vital for maintaining homeostasis and disease progression, highlighting the significance of EVs in health and disease.

Purpose of the Study:

  • To review recent studies on the contents and biological functions of extracellular vesicles (EVs).
  • To focus on the potential role of EVs in atherosclerosis.
  • To explore EVs as potential biomarkers and therapeutic targets for atherosclerotic diseases.

Main Methods:

  • Literature review of recent studies on extracellular vesicles.
  • Analysis of EV contents and biological functions.
  • Focus on the involvement of EVs in key steps of atherosclerosis.

Main Results:

  • EVs are involved in multiple biological processes relevant to cardiovascular health and disease.
  • EVs play a significant role in atherosclerosis, influencing cellular lipid metabolism, endothelial dysfunction, and vascular inflammation.
  • EVs are associated with vascular remodeling, angiogenesis, and coagulation in the context of atherosclerosis.

Conclusions:

  • Extracellular vesicles are integral to the pathogenesis of atherosclerosis.
  • EVs hold promise as potential biomarkers for diagnosing and monitoring atherosclerotic diseases.
  • EVs represent promising targets for the development of novel pharmacological interventions against atherosclerosis.