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Updated: Jan 26, 2026

Development of an In Vitro Ocular Platform to Test Contact Lenses
Published on: April 6, 2016
Ocular biopharmaceutics: impact of modeling and simulation on topical ophthalmic formulation development
Hovhannes J Gukasyan1, Shumet Hailu1, Thomas K Karami1
1Early Pharmaceutical Development, Allergan plc, 2525 Dupont Drive, Irvine, CA, 92612, United States.
Abstract:
The estimation of ocular pharmacokinetics (PK) in various eye tissues is limited because of sampling challenges. Computational modeling and simulation (M&S) tools underpinning the elucidation of drug access routes and prediction of ocular exposure are essential for the mechanistic assessment of biopharmaceutics in the eye. Therefore, theoretical and experimental evaluation of ocular absorption and transit models is necessary. Biopharmaceutical parameter sensitivity analysis based on permeability and drug dose illustrates utility in ocular drug delivery assessment, which could have innovative and cost-saving impacts on ophthalmic product development and therapeutic bioequivalence (BE) evaluations.
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