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CD5L contributes to the pathogenesis of methicillin-resistant Staphylococcus aureus-induced pneumonia

Xun Gao1, Xingxing Yan2, Qun Zhang3

  • 1Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Key Laboratory of Diagnostic Medicine designated by the Ministry of Education, Chongqing Medical University, Chongqing, China.

International Immunopharmacology
|April 9, 2019
PubMed

Insights

This study reveals that CD5L protein levels increase during Staphylococcus aureus pneumonia. Targeting CD5L with an antibody improved survival by reducing inflammation and bacterial load in mice.

Area of Science:

  • Immunology
  • Microbiology
  • Pulmonology

Background:

  • Staphylococcus aureus is a primary cause of community- and healthcare-acquired pneumonia.
  • CD5L is a key regulator of immune homeostasis.

Purpose of the Study:

  • To investigate the role of CD5L in Staphylococcus aureus pneumonia.
  • To evaluate the therapeutic potential of targeting CD5L in S. aureus pneumonia.

Main Methods:

  • Measurement of CD5L levels in patients and mice with S. aureus pneumonia.
  • Administration of anti-CD5L antibody or recombinant CD5L in a mouse model.
  • Assessment of bacterial clearance, survival rates, and pulmonary inflammatory markers.

Main Results:

  • Elevated circulating and lung CD5L levels were observed in S. aureus pneumonia.
  • Anti-CD5L antibody treatment enhanced survival, bacterial clearance, and reduced pulmonary inflammation.
  • Recombinant CD5L exacerbated S. aureus pneumonia lethality.

Conclusions:

  • CD5L plays a significant role in the immunopathology of S. aureus pneumonia.
  • Targeting CD5L represents a potential therapeutic strategy for S. aureus pneumonia.
Keywords:
CD5LInfectionPneumoniaStaphylococcus aureus

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