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Updated: Jan 26, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Synthesis of het(aryl) imidazole C-nucleoside analogues by CoFe2O4 NPs catalyzed muti-component coupling reaction
Fuyi Zhang1, Yang Li1, Fei Gao1
1The College of Chemistry and Molecular Engineering, The Key Lab of Chemical Biology and Organic Chemistry, Zhengzhou University, Zhengzhou, China.
Abstract:
A general synthesis of hetaryl and aryl C-4(5) linked imidazole C-nucleoside analogues has been developed by the reaction of sugar alkynes with het(aryl) iodides, KMnO4/TBAB oxidation and CoFe2O4 NPs catalyzed muti-component coupling of the corresponding diketones, NH4OAc and aromatic aldehydes in one-pot. The sugar alkynes include pyranosides and furanosides with acid sensitive protecting groups. The het(aryl) iodides comprise iodoaromatics, iodoheterocycles, and sterically hindered iodoheteroaromatics.
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