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Updated: Jan 26, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Low Provider Knowledge Is Associated With Less Evidence-Based Lung Cancer Screening
Jennifer A Lewis1,2, Heidi Chen3, Kathryn E Weaver4
1aGeriatric Research, Education and Clinical Center, Veterans Health Administration - Tennessee Valley Healthcare System, Nashville, Tennessee.
Low provider knowledge of lung cancer screening (LCS) guidelines is linked to reduced low-dose CT (LDCT) orders. Improving provider education is crucial for effective LCS implementation in at-risk populations.
Area of Science:
- Pulmonology
- Radiology
- Healthcare Policy
Background:
- Lung cancer screening (LCS) with low-dose CT (LDCT) is recommended but underutilized in the US.
- Low provider knowledge of LCS guidelines is a potential barrier to screening implementation.
Purpose of the Study:
- To test the hypothesis that low provider knowledge of LCS guidelines is associated with less provider-reported screening with LDCT.
Main Methods:
- A cross-sectional survey assessed LCS guideline knowledge among providers treating patients over 50.
- High knowledge was defined by identifying 3 key eligibility criteria; low knowledge was defined by not identifying them.
- Provider-reported LDCT orders/referrals in the past year were the primary outcome.
Main Results:
- 62% of providers demonstrated low LCS knowledge, and 59% reported ordering/referring for LDCT.
- Providers with low knowledge had significantly lower odds of ordering/referring for LDCT (aOR, 0.41).
- Providers with low knowledge were more likely to order screening chest radiographs (aOR, 2.7).
Conclusions:
- Provider knowledge of LCS guidelines is low and directly correlates with LDCT ordering rates.
- Strategies to improve LCS should include provider education and system-level interventions to address knowledge gaps.
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