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Leptin resensitisation: a reversion of leptin-resistant states
María F Andreoli1,2, Jose Donato3, Isin Cakir4,5
1Laboratory of Experimental Neurodevelopment, Institute of Development and Paediatric Research (IDIP), La Plata Children's Hospital and Scientific Research Commission, Province of Buenos Aires (CIC-PBA), La Plata, Buenos Aires, Argentina.
The Journal of Endocrinology
|April 9, 2019
Summary
Leptin resistance, common in obesity, occurs when leptin fails to work. Leptin resensitisation, or restoring leptin sensitivity, can help treat obesity and prevent weight regain.
Area of Science:
- Endocrinology
- Metabolic Science
- Obesity Research
Background:
- Leptin resistance is a state where leptin's effects are diminished, often with high leptin levels (hyperleptinaemia).
- This condition is linked to obesity, pregnancy, and seasonal animals.
- Leptin resensitisation signifies a return to leptin sensitivity, improving metabolic issues.
Purpose of the Study:
- To review and discuss the reversion of leptin-resistant states.
- To explore the modulation of molecular mechanisms underlying leptin resistance and resensitisation.
- To highlight the therapeutic potential of restoring leptin sensitivity for obesity management.
Main Methods:
- This is a review article, synthesizing existing research.
- It discusses molecular mechanisms involved in leptin resistance.
- It analyzes strategies for leptin resensitisation in different physiological and pathological states.
Main Results:
- Leptin resistance is associated with hyperleptinaemia and metabolic disturbances.
- Leptin resensitisation leads to improved endocrine and metabolic function and reduced leptin levels.
- In obesity, resensitisation can be achieved through weight reduction or pharmacological agents.
- Physiological leptin resistance typically resolves spontaneously.
Conclusions:
- Restoring leptin sensitivity is a promising strategy for obesity treatment.
- Leptin resensitisation may aid in weight loss maintenance and reduce weight regain.
- Understanding the molecular basis of leptin resistance is crucial for developing effective therapies.
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