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Related Concept Videos

Transcription Factors02:16

Transcription Factors

82.4K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.4K
Transcription Elongation Factors02:35

Transcription Elongation Factors

13.6K
Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
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Transcription Elongation Factors02:35

Transcription Elongation Factors

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General Transcription Factors01:30

General Transcription Factors

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
6.8K
Transcription01:10

Transcription

155.9K
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
155.9K
Master Transcription Regulators02:23

Master Transcription Regulators

7.7K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.7K

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Related Experiment Video

Updated: Jan 26, 2026

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

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ApiAP2 Transcription Factors in Apicomplexan Parasites.

Myriam D Jeninga1, Jennifer E Quinn2, Michaela Petter3,4

  • 1Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, 91054 Erlangen, Germany. myriam.jeninga@uk-erlangen.de.

Pathogens (Basel, Switzerland)
|April 10, 2019
PubMed
Summary

Apicomplexan parasites, like the malaria parasite, use ApiAP2 transcription factors to control their complex life cycles. This review details recent findings on these crucial regulators in apicomplexan parasites.

Keywords:
ApiAP2ApicomplexaCryptosporidiumPlasmodiumToxoplasmadifferentiationgene regulationmalariatranscription factor

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Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
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Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
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Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

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Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
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Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
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Area of Science:

  • Parasitology
  • Molecular Biology
  • Genetics

Background:

  • Apicomplexan parasites are protozoan organisms with complex life cycles, including medically significant species like Plasmodium (malaria), Toxoplasma gondii (toxoplasmosis), and Cryptosporidium.
  • These parasites undergo developmental transitions between morphologically and metabolically distinct stages within one or more hosts.
  • Such transitions are regulated by changes in gene expression.

Purpose of the Study:

  • To review recent advancements in understanding the ApiAP2 transcription factor family in apicomplexan parasites.
  • To highlight the roles of ApiAP2 members in regulating apicomplexan parasite life cycle transitions and other biological processes.

Main Methods:

  • Literature review of recent research on ApiAP2 transcription factors in apicomplexan parasites.
  • Synthesis of findings on the functions of various ApiAP2 family members.

Main Results:

  • The ApiAP2 transcription factor family plays critical roles in regulating apicomplexan parasite biology.
  • Specific ApiAP2 members have been identified as key regulators of life cycle transitions.
  • Understanding these factors is crucial for comprehending parasite development and pathogenesis.

Conclusions:

  • ApiAP2 transcription factors are essential regulators of apicomplexan parasite development.
  • Further research into the ApiAP2 family will provide deeper insights into apicomplexan biology and potential therapeutic targets.