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Updated: Jan 26, 2026

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
Published on: April 28, 2015
Preparation of Prussian Blue Containing Polymeric Nanocapsule via Interfacial Confined Coordination in Crosslinked
Lin Wu1, Tao Pang2, Yebin Guan3
1Anhui Key Laboratory of Functional Coordination Compounds, School of Chemistry and Chemical Engineering, Anqing Normal University, Anqing, Anhui 246011, China. wulinaqsfxy@163.com.
Abstract:
This work presents a simple and facile strategy for the creation of Prussian blue containing polymeric nanocapsules. An crosslinked inverse miniemulsion with a formula of water/ K₄Fe(CN)₆/1,2-bis-(-2-iodoethyl) ethane(BIEE)/ toluene/ PDMAEMA-b-PS stabilizer mixture was prepared as soft template firstly. A crosslinking nanocapsule structure with K₄Fe(CN)₆ in water core could be achieved by a crosslinking reaction between PDMAEMA-b-PS stabilizers and BIEE. Upon the following addition of FeCl₃ ether solution into the oil phase of this inverse miniemulsion, a coordination reaction between two iron salts occurred immediately to form a Prussian blue complex. Due to the solubility limitation of FeCl₃ in the oil phase of the miniemulsion, forcing the coordination reaction of K₄Fe(CN)₆ and FeCl₃ mainly occurred at the oil-water interface of the nanocapsules, resulting in a soft polymer/Prussian blue(PB) hybrid nanocapsule.
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