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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
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Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
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Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Supramolecular Cyclodextrin-Based Hydrogels for Controlled Gene Delivery.

Ana Rey-Rico1, Magali Cucchiarini2

  • 1Cell Therapy and Regenerative Medicine Unit, Centro de Investigacións Científicas Avanzadas (CICA), Universidade da Coruña, Campus de A Coruña, 15071 A Coruña, Spain. ana.rey.rico@udc.es.

Polymers
|April 10, 2019
PubMed
Summary
This summary is machine-generated.

Cyclodextrin-based hydrogels offer controlled gene delivery for regenerative medicine. These injectable biomaterials act as depots, ensuring sustained local availability of gene transfer vectors.

Keywords:
controlled gene deliverycyclodextrin-based polypseudorotaxane hydrogelsgene transfernonviral vectorssupramolecular hydrogelsviral vectors

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Area of Science:

  • Biomaterials Science
  • Gene Therapy
  • Regenerative Medicine

Background:

  • Controlled gene delivery enhances therapeutic agent presentation at target sites.
  • Hydrogels serve as localized depots for sustained availability of gene transfer vectors.
  • Supramolecular hydrogels, particularly those based on cyclodextrins (CDs), are promising biomaterials for drug delivery.

Purpose of the Study:

  • To provide an overview of cyclodextrin-based polypseudorotaxane hydrogels for controlled gene delivery.
  • To highlight their potential applications in regenerative medicine.

Main Methods:

  • Review of supramolecular hydrogels based on cyclodextrins.
  • Focus on polypseudorotaxane hydrogel systems.
  • Evaluation of injectable delivery system characteristics.

Main Results:

  • Cyclodextrin-based hydrogels exhibit thixotropic properties and low cytotoxicity.
  • These hydrogels can be produced under mild conditions, suitable for injectable systems.
  • Polypseudorotaxane hydrogels demonstrate potential as controlled gene delivery depots.

Conclusions:

  • CD-based polypseudorotaxane hydrogels are suitable for controlled gene delivery.
  • Their properties make them ideal for localized, long-term gene vector availability.
  • These hydrogels hold significant promise for regenerative medicine applications.