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Related Experiment Video

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Generation of Alginate Microspheres for Biomedical Applications
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Stimuli-Responsive Polypeptides for Biomedical Applications.

DaeYong Lee1, N Sanoj Rejinold2, Seong Dong Jeong3

  • 1Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. winleeok@kaist.ac.kr.

Polymers
|April 10, 2019
PubMed
Summary
This summary is machine-generated.

Stimuli-responsive polypeptides offer tunable bioactive properties with biocompatibility. This review covers recent advances in polypeptides responding to pH, redox, glucose, ATP, and enzymes for biomedical applications.

Keywords:
drug and gene delivery systemspolypeptides-based materialsstimuli-responsiveness

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Stimuli-responsive polypeptides are gaining attention for their tunable bioactive properties.
  • These polypeptides maintain inherent biocompatibility and biodegradability.
  • Recent advancements focus on enhancing their utility in biomedical fields.

Purpose of the Study:

  • To review recent advances in stimuli-responsive polypeptides over the past five years.
  • To highlight various synthetic strategies for creating advanced polypeptide-based materials.
  • To discuss the biomedical applicability of these novel materials.

Main Methods:

  • Literature review of stimuli-responsive polypeptide research from the last five years.
  • Analysis of synthetic strategies for polypeptide material development.
  • Evaluation of the biomedical applications of diverse stimuli-responsive polypeptides.

Main Results:

  • Summary of recent progress in polypeptides responsive to pH, reduction, oxidation, glucose, adenosine triphosphate (ATP), and enzymes.
  • Introduction of novel synthetic approaches for polypeptide-based materials.
  • Discussion of the expanding applicability of these materials in biomedicine.

Conclusions:

  • Stimuli-responsive polypeptides represent a versatile platform for advanced biomedical materials.
  • Novel synthetic strategies are enabling new functionalities and properties.
  • Continued research promises significant impact in various therapeutic and diagnostic areas.