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Operation of a Benchtop Bioreactor
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Bioreactor Operating Strategies for Improved Polyhydroxyalkanoate (PHA) Productivity.

Warren Blunt1, David B Levin2, Nazim Cicek3

  • 1Department of Biosystems Engineering, University of Manitoba, Winnipeg, MB R3T 5V6, Canada. umbluntw@myumanitoba.ca.

Polymers
|April 10, 2019
PubMed
Summary
This summary is machine-generated.

Microbial polyhydroxyalkanoates (PHAs) offer a biodegradable alternative to plastics. This review summarizes bioreactor strategies for enhancing PHA production, focusing on pure cultures and cost-effective methods.

Keywords:
PHAsbioreactorcontinuous fermentationfed-batch fermentationpolyhydroxyalkanoatesproductivityscale-up

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Area of Science:

  • Biotechnology
  • Polymer Science
  • Environmental Science

Background:

  • Microbial polyhydroxyalkanoates (PHAs) are biodegradable polymers with potential to reduce reliance on petroleum-based plastics.
  • High production costs and environmental impact of PHAs are linked to carbon substrate and energy requirements for bioreactor operations.
  • Improving process productivity is crucial for reducing PHA production costs.

Purpose of the Study:

  • To review bioreactor operations that target high polyhydroxyalkanoate (PHA) productivity using pure cultures.
  • To assess strategies for cost reduction and environmental impact mitigation in PHA bioproduction.
  • To identify advancements and limitations in bioreactor systems for PHA manufacturing.

Main Methods:

  • Review of existing literature on bioreactor operations for PHA production.
  • Analysis of fed-batch, continuous, and semi-continuous bioreactor systems.
  • Focus on pure culture studies targeting high volumetric productivity.

Main Results:

  • The highest reported volumetric PHA productivity (5.1 g L-1 h-1) for poly(3-hydroxybutyrate) (PHB) from sucrose was achieved over 20 years ago and not replicated at scales >100 L.
  • Recent fed-batch and semi-continuous strategies achieve 1-2 g L-1 h-1 under realistic pilot/industrial conditions.
  • These recent strategies utilize cost-effective waste carbon substrates, atmospheric air for aeration, and non-sterile cultivation.

Conclusions:

  • While historical records show high PHA productivity, recent advancements focus on practical, scalable, and cost-effective methods.
  • Fed-batch and semi-continuous bioreactor operations show promise for industrial PHA production using sustainable feedstocks.
  • Further development in fully continuous bioreactor systems for PHA production has been limited in recent years.