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Updated: Jan 26, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Diterpenoids isolated from the root of Salvia miltiorrhiza and their anti-inflammatory activity
Thi Men Ngo1, Phuong Thao Tran2, Le Son Hoang3
1College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, Republic of Korea.
Abstract:
Four new diterpene-type compounds normiltirone (3) and isosalviamides F-H (14-16) together with twelve known compounds (1, 2, 4-13) were isolated from the roots of Salvia miltiorrhiza. Their structures were mainly elucidated from detailed spectroscopic data. All isolated compounds were evaluated for their ability to inhibit lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages. Compound 11 showed a strong inhibitory effect, with an IC50 value of 3.4 ± 1.2 μM.
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