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Liposomes in Active, Passive and Acoustically-Triggered Drug Delivery

Sara Al Basha1, Najla Salkho2, Sarah Dalibalta1

  • 1Department of Chemistry, Biology and Environmental Sciences, American University of Sharjah, Sharjah, United Arab Emirates.

Mini Reviews in Medicinal Chemistry
|April 10, 2019
PubMed

Insights

Nanocarrier systems like liposomes offer targeted cancer treatment, improving chemotherapy efficacy and reducing side effects. This research explores passive, active, and ultrasound-triggered delivery methods for better drug delivery to tumors.

Area of Science:

  • Oncology
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Cancer is a leading global noncommunicable disease with limited effective treatments.
  • Conventional chemotherapy lacks specificity, causing severe side effects by damaging healthy tissues.
  • Nanocarrier systems are being developed to improve targeted drug delivery and minimize toxicity.

Purpose of the Study:

  • To review liposomes as nanocarriers for anticancer drug delivery.
  • To discuss passive, active, and ultrasound-triggered drug delivery strategies.
  • To highlight advancements in targeted cancer therapy.

Main Methods:

  • Literature review of nanocarrier systems in cancer therapy.
  • Focus on liposome-based drug delivery mechanisms.
  • Analysis of passive, active, and ultrasound-triggered targeting approaches.

Main Results:

  • Liposomes can encapsulate chemotherapeutic drugs for targeted delivery.
  • Passive targeting relies on the enhanced permeability and retention (EPR) effect.
  • Active targeting utilizes ligands for specific cell receptor binding.
  • Ultrasound-triggered delivery enhances drug release at the tumor site.

Conclusions:

  • Nanocarrier systems, particularly liposomes, show promise in enhancing cancer treatment efficacy.
  • Targeted delivery strategies significantly reduce chemotherapy-induced side effects.
  • Further research into advanced nanocarrier systems is crucial for improved patient outcomes.
Keywords:
Drug deliveryactive targetingliposomespassive targetingtriggered targetingultrasound.

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