Related Experiment Video
Updated: Jan 26, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
AK-968 efficiently inhibits proliferation and induces cell apoptosis in human multiple myeloma cells
Abstract:
AK-968 is a small molecular weight compound. In this study, we evaluated its anti-tumor effects on human multiple myeloma (MM) cells. Our results demonstrated that AK-968 markedly inhibited proliferation of MM cell lines in a dose-and time-dependent manner. Additionally, our flow cytometry data showed that MM cell apoptosis was significantly induced by AK-968. As expected, caspase-3 cleavage and alternation of mitochondrial membrane potential (MMP) in the MM cells treated by AK-968 was detected or quantified by Western Blot or Flow cytometry technique, respectively. In conclusion, our results suggested that AK-968 may act as a potential drug to treat human multiple myeloma.
More Related Videos
Related Concept Videos
Cells Coordinate Growth and Proliferation
Apoptosis
Induced Pluripotent Stem Cells
Induced Pluripotent Stem Cells
Somatic...
Feedback Inhibition
Multiple Allele Traits

