Diagnosis of Canine Leptospirosis

Several diagnostic tests are available to aid veterinarians in diagnosis of leptospirosis. Understanding the course of infection is imperative to determining which diagnostic test to order and sample to submit. Diagnostic tests for dogs suspected of having leptospirosis include antibody-based tests and polymerase chain reaction (PCR). Paired acute and convalescent microscopic agglutination test (MAT) are diagnostic for leptospirosis. PCR performed on blood and/or urine can be a valuable tool to aid in diagnosis of leptospirosis. Commercially available rapid point-of-care diagnostics have been validated in dogs and have value early in the course of illness before MAT and PCR results are available.