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Related Concept Videos

Responses to Salt Stress02:02

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Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
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Responses to Heat and Cold Stress02:45

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The general state of stress within a material can be accurately depicted using a stress tensor. This tensor encapsulates the internal forces distributed within a material subjected to external forces or deformations.
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Stress01:20

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When a force is applied on a body, it undergoes deformation. In order to restore the body to its original shape and/or size, an opposite or restoring force is generated within the body. This restoring force is equal to the magnitude of the applied force, but acts in the opposite direction. The amount of this restoring force developed per unit area of the body is called stress. Stress is a tensor quantity and has the SI unit pascal. Stress can be separated into four broad categories depending...
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Personality types, particularly Type A and Type B, significantly influence how individuals respond to stress. These personality distinctions are marked by varying levels of ambition, competitiveness, and coping styles, all of which shape an individual's resilience to stressors.
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Stress prevention and management are crucial for maintaining well-being and building resilience. Techniques to manage stress include cultivating qualities like conscientiousness, a sense of personal control, and self-efficacy. Each of these traits significantly reduces stress and promotes healthier lifestyle choices and outcomes.
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Updated: Jan 26, 2026

Quantifying Replication Stress in Ovarian Cancer Cells Using Single-Stranded DNA Immunofluorescence
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Cancer Cells Thrive on Stress.

Lorenzo Galluzzi1, Guido Kroemer2

  • 1Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Department of Dermatology, Yale School of Medicine, New Haven, CT, USA; Université Paris Descartes, Paris, France.

Trends in Cell Biology
|April 10, 2019
PubMed
Summary

Glucocorticoids (GCs) are commonly used in cancer care. However, activating GC receptors (GRs) may accelerate breast cancer spread and survival at new sites, suggesting a need to reconsider their use.

Keywords:
ROR1circulating tumor cellsdormancyimmunotherapysocial stresstriple negative breast cancer

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Area of Science:

  • Oncology
  • Endocrinology
  • Molecular Biology

Background:

  • Glucocorticoids (GCs) are frequently prescribed to manage complications in cancer patients.
  • The role of GCs in cancer progression is an area of ongoing investigation.

Purpose of the Study:

  • To investigate the impact of glucocorticoid receptor (GR) activation on breast cancer progression.
  • To evaluate the potential role of GCs in promoting metastatic dissemination and tumor cell survival.

Main Methods:

  • Analysis of recent data on GC receptor activation.
  • Evaluation of mechanisms driving cancer metastasis and cell survival.

Main Results:

  • Activation of GC receptors (GRs) is linked to increased breast cancer progression.
  • GC receptor activation appears to facilitate metastatic dissemination.
  • GCs may enhance cancer cell survival at distant metastatic sites.

Conclusions:

  • Glucocorticoid receptor activation plays a role in promoting breast cancer progression and metastasis.
  • The findings necessitate a re-evaluation of glucocorticoid administration in cancer patients.
  • Further research is warranted to understand the precise mechanisms and clinical implications.