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[Free radical toxicity in coronary insufficiency]
Archives Des Maladies Du Coeur Et Des Vaisseaux
|June 1, 1986
Summary
Patients with myocardial infarction and preinfarction syndrome show elevated malondialdehyde (MDA) levels, indicating ongoing lipid peroxidation. MDA levels decrease after infarction but remain high in unstable preinfarction patients, suggesting continued membrane damage.
Area of Science:
- Biochemistry
- Cardiology
- Oxidative Stress
Background:
- Myocardial ischemia is associated with increased cytotoxic oxygen-derived free radicals (FR).
- FR cause membrane lipid peroxidation (MLP), producing harmful endoperoxides.
- Malondialdehyde (MDA) is an indicator of MLP.
Purpose of the Study:
- To investigate plasma MDA concentrations in patients with preinfarction syndrome and acute myocardial infarction.
- To assess MDA as a marker of ongoing MLP in these cardiac conditions.
Main Methods:
- Plasma MDA levels were measured in 10 preinfarction patients (Group 1) and 8 acute myocardial infarction patients (Group 2).
- Measurements were taken on admission (P1) and the 12th day (P3), with peak MDA values noted.
- Patient data were compared to 15 age-matched healthy controls.
Main Results:
- Both patient groups exhibited significantly elevated MDA levels on admission compared to controls (p < 0.01).
- MDA levels in the acute infarction group decreased significantly by day 12 (189 ng/ml) from peak levels (258 ng/ml).
- Preinfarction patients with persistent unstable angina had persistently high MDA levels (250 ng/ml) on day 12.
Conclusions:
- Elevated plasma MDA indicates ongoing membrane lipid peroxidation in preinfarction and acute myocardial infarction.
- Decreasing MDA levels post-infarction suggest resolution of MLP.
- Persistently high MDA in preinfarction syndrome patients correlates with ongoing unstable angina and MLP.