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Updated: Jan 26, 2026

Measuring Active and Passive Tameness Separately in Mice

Measuring Active and Passive Tameness Separately in Mice

Published on: August 10, 2018

When pregnancy tames the wolf.

Timothy B Niewold¹, Shilpi Mehta-Lee²

¹Departments of Medicine and Pathology, Colton Center for Autoimmunity, New York University School of Medicine, New York, NY Timothy.Niewold@nyulangone.org.

The Journal of Experimental Medicine

|April 10, 2019

Summary

This summary is machine-generated.

Pregnancy involves immune changes. Researchers found that inflammation signatures in pregnant women with lupus that did not normalize increased the risk of pregnancy complications.

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Area of Science:

Immunology
Obstetrics
Genetics

Background:

Normal pregnancy is characterized by a state of relative immunosuppression.
Understanding immune modulation during pregnancy is crucial for managing pregnancy-related complications.

Purpose of the Study:

To investigate blood immune profiles during pregnancy in healthy women and those with systemic lupus erythematosus (SLE).
To identify early transcriptional changes related to lupus and their association with pregnancy outcomes.

Main Methods:

Blood immunomonitoring was performed on pregnant women, including healthy individuals and those diagnosed with lupus.
Transcriptional analysis focused on lupus-related pathways to detect early and sustained modulations.

Main Results:

Both healthy pregnant women and those with lupus exhibited early and sustained transcriptional modulation of lupus-related pathways.
Failure of inflammation signatures to normalize in pregnant women with lupus was correlated with an increased risk of pregnancy complications.

Conclusions:

Pregnancy induces significant immune transcriptional changes, even in healthy individuals.
Persistent inflammation in pregnant women with lupus is a key indicator of heightened risk for adverse pregnancy outcomes.