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Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
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Primary Regressive, But Metastasizing Melanoma!?

Georgi Tchernev1,2, Ivanka Temelkova1,2

  • 1Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic Surgery, General Skobelev 79, 1606 Sofia, Bulgaria.

Open Access Macedonian Journal of Medical Sciences
|April 10, 2019
PubMed
Summary

Regressive melanomas can still metastasize, posing diagnostic challenges. Early adjuvant therapy may benefit patients with stage III melanoma, even if the primary tumor has regressed.

Keywords:
Early adjuvant therapyMetastasizing melanomaPrognosisRegressive melanoma

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Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Regressive melanomas present diagnostic and therapeutic challenges due to asynchronous tumor progression and metastasis.
  • Melanoma regression does not preclude the development of locoregional or distant metastases.
  • Prognosis in regressive melanoma with metastasis can vary based on metastasis characteristics.

Purpose of the Study:

  • To discuss the prognosis and therapeutic strategies for regressive melanomas with subsequent lymph node metastasis.
  • To explore the role of early adjuvant therapy in managing stage III melanoma.

Main Methods:

  • Case report of a 42-year-old patient with melanoma metastasis to inguinal lymph nodes.
  • Histopathological examination and BRAF mutation testing.
  • Analysis of patient history including a regressed primary lesion.

Main Results:

  • The patient presented with enlarged inguinal lymph nodes, confirmed as melanoma metastasis.
  • BRAF mutation was detected.
  • The primary lesion on the thigh had regressed prior to lymph node metastasis detection.

Conclusions:

  • There is no consensus on early adjuvant therapy for regressive melanomas.
  • Early adjuvant therapy might be beneficial for stage III melanoma patients.
  • Management of regressive melanoma with metastasis requires careful consideration of prognosis and treatment options.