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Mechanism of mannose toxicity.

M de la Fuente, P F Peñas, A Sols

    Biochemical and Biophysical Research Communications
    |October 15, 1986
    PubMed
    Summary

    Mannose is toxic to honeybees due to low mannosephosphate isomerase, causing ATP depletion. Other insects are resistant, suggesting a hexosephosphate accumulation mechanism for mannose toxicity.

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    Area of Science:

    • Biochemistry
    • Insect Physiology
    • Toxicology

    Background:

    • Mannose toxicity affects honeybees, leading to ATP depletion.
    • Enzyme levels, specifically mannosephosphate isomerase and hexokinase, vary between sensitive and insensitive insects.

    Purpose of the Study:

    • To investigate the biochemical mechanism of mannose toxicity in honeybees.
    • To compare the enzymatic basis of mannose sensitivity in honeybees versus other insect species.

    Main Methods:

    • Enzyme assays were performed to quantify mannosephosphate isomerase and hexokinase levels.
    • Toxicity of mannose and 2-deoxyglucose was assessed in honeybees and other insects.

    Main Results:

    • Honeybees exhibit a shortage of mannosephosphate isomerase, leading to mannose-6-P accumulation and ATP depletion.
    • Drosophila melanogaster and Ceratitis capitata are insensitive to mannose and possess higher mannosephosphate isomerase relative to hexokinase.
    • 2-Deoxyglucose shows toxicity similar to mannose in honeybees and other insects.

    Conclusions:

    • Mannose toxicity in honeybees is linked to insufficient mannosephosphate isomerase activity.
    • The accumulation of hexosephosphates is a key factor in mannose-induced toxicity across studied insects.

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