Quantitative contrast-enhanced US helps differentiating neoplastic vs non-neoplastic gallbladder polyps
Jae Seok Bae1,2, Se Hyung Kim3,4,5, Hyo-Jin Kang1,2
1Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
European Radiology
|April 10, 2019
Summary
Quantitative analysis of contrast-enhanced ultrasound (CEUS) can differentiate large gallbladder polyps. This method accurately distinguishes neoplastic from non-neoplastic polyps, aiding in diagnosis.
Area of Science:
- Medical Imaging
- Gastroenterology
- Oncology
Background:
- Gallbladder polyps larger than 1 cm require differentiation between neoplastic and non-neoplastic types.
- Accurate differentiation is crucial for appropriate clinical management and surgical planning.
Purpose of the Study:
- To assess the utility of quantitative contrast-enhanced ultrasound (CEUS) in differentiating large (≥1 cm) neoplastic from non-neoplastic gallbladder polyps.
- To evaluate the diagnostic performance of quantitative CEUS parameters.
Main Methods:
- 29 patients with large gallbladder polyps underwent conventional ultrasound and CEUS.
- Quantitative analysis of CEUS time-intensity curves was performed by two radiologists.
- Receiver operating characteristic analysis was used to determine diagnostic performance.
Main Results:
- Quantitative CEUS parameters (rise time, mean transit time, time to peak, fall time) were significantly different between neoplastic and non-neoplastic polyps.
- Interobserver agreement for quantitative analysis was near-perfect to substantial.
- Sensitivity ranged from 76.5-100% and specificity was 75% for differentiation.
Conclusions:
- Quantitative analysis of CEUS findings is valuable for differentiating gallbladder neoplastic polyps from non-neoplastic polyps.
- CEUS provides cut-off values for differentiation with high interobserver agreement.
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