Related Experiment Video
Updated: Jan 26, 2026
08:07
Traditional Trail Making Test Modified into Brand-new Assessment Tools: Digital and Walking Trail Making Test
Published on: November 23, 2019
11.8K
Mild cognitive impairment in Parkinson's disease
Saul Martinez-Horta1,2,3,4, Jaime Kulisevsky5,6,7,8
1Movement Disorders Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Journal of Neural Transmission (Vienna, Austria : 1996)
|April 10, 2019
Summary
Parkinson's disease (PD) patients often have cognitive impairment at diagnosis, impacting daily function. Early executive deficits and posterior-cortical changes are key to understanding PD-MCI progression to dementia.
Area of Science:
- Neurology
- Neuroscience
- Cognitive Science
Background:
- Cognitive impairment and dementia are common in Parkinson's disease (PD).
- Even mild cognitive changes in PD significantly impact functional capacity.
- Early executive deficits are characteristic of cognitive impairment in PD.
Purpose of the Study:
- To review the clinical features and neural mechanisms of cognitive deterioration in PD.
- To describe diagnostic criteria for Parkinson's disease with mild cognitive impairment (PD-MCI) and dementia (PDD).
- To outline recommended cognitive assessment approaches for PD.
Main Methods:
- Review of existing literature on cognitive impairment in Parkinson's disease.
- Analysis of clinical features and neural mechanisms.
- Examination of diagnostic criteria and assessment guidelines for PD-MCI and PDD.
Main Results:
- Nearly all PD patients exhibit some cognitive impairment at diagnosis.
- Executive deficits are prominent in early stages of PD cognitive impairment.
- Posterior-cortical impairment plays a transitional role in PD-MCI progression to dementia.
Conclusions:
- The pattern of cognitive impairment in PD is variable.
- Specific diagnostic criteria and assessment guidelines for PD-MCI and PDD have been developed.
- Understanding cognitive deterioration profiles is crucial for managing PD.