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Inflammation associated with chronic heart failure leads to enhanced susceptibility to depression

Jing Su1,2, Jinghui Wang1, Yuanyuan Ma1

  • 1Department of Translational Neuroscience, Jing' an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology & Institutes of Brain Science, Fudan University, China.

The FEBS Journal
|April 10, 2019
PubMed

Insights

Chronic heart failure (CHF) can lead to depression in susceptible individuals. Long-term heart failure increases central nervous system inflammation, impacting brain function and behavior.

Area of Science:

  • Cardiology
  • Neuroscience
  • Psychiatry

Background:

  • A high risk for depression exists in patients with chronic heart failure (CHF).
  • The causal relationship and underlying mechanisms between CHF and depression are not well understood.

Purpose of the Study:

  • To investigate behavioral changes and brain-heart axis alterations in mice with myocardial infarction and CHF.
  • To identify mechanisms linking long-term CHF to depression.

Main Methods:

  • Mice underwent myocardial infarction to induce CHF.
  • Behavioral tests, including the sucrose preference test, were used over 9 months.
  • Brain-heart axis markers, including neurotransmission, HPA axis activation, synaptic plasticity, inflammation, and kynurenine metabolism, were analyzed.

Main Results:

  • CHF mice developed neuropsychiatric abnormalities.
  • Two subgroups emerged: susceptible (Sus) mice with decreased sucrose preference and resilient mice.
  • Sus mice showed glutamate transmission imbalances, HPA axis activation, impaired synaptic plasticity, increased inflammation, and altered kynurenine metabolism.

Conclusions:

  • Long-term CHF is associated with significant changes in the brain-heart axis.
  • Increased central nervous system inflammation and altered neurochemical pathways contribute to depression in susceptible individuals with CHF.

Keywords:
chronic heart failuredepressionkynurenine metabolismresilientsusceptible

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