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Fluorimetric Techniques for the Assessment of Sperm Membranes
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Redox regulation & sperm function: A proteomic insight.

Gayatri Mohanty1, Luna Samanta1

  • 1Department of Zoology, Redox Biology Laboratory, Ravenshaw University, Cuttack, India.

The Indian Journal of Medical Research
|April 10, 2019
PubMed
Summary
This summary is machine-generated.

Male infertility affects 50% of couples, often due to oxidative stress impacting sperm function. Proteomic technology offers new therapeutic and contraceptive strategies by targeting altered sperm proteins.

Keywords:
Male contraceptionmale infertilityproteomicsreactive oxygen species

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Area of Science:

  • Reproductive Biology
  • Biochemistry
  • Genetics

Background:

  • Male factor infertility affects approximately 50% of infertile couples globally.
  • Spermatozoa require specific redox regulation for fertilizing ability, with reactive oxygen species (ROS) playing a dual role.
  • High concentrations of ROS induce oxidative stress (OS), impairing sperm function and leading to infertility.

Purpose of the Study:

  • To review the role of oxidative stress in male infertility.
  • To highlight the application of high-throughput proteomic technology in addressing OS-related male infertility.
  • To explore the potential of targeting altered sperm proteins for male contraceptive development.

Main Methods:

  • Review of current literature on male infertility, oxidative stress, and proteomics.
  • Discussion of redox mechanisms regulating sperm function.
  • Analysis of proteomic approaches for identifying OS-mediated protein alterations in spermatozoa.

Main Results:

  • Oxidative stress significantly impacts sperm chromatin integrity and function.
  • Proteomic technologies enable the identification of specific protein changes associated with OS in infertile males.
  • These identified proteins represent potential targets for therapeutic interventions and male contraception.

Conclusions:

  • Targeting OS-mediated protein alterations in spermatozoa is a promising therapeutic strategy for male infertility.
  • Proteomic insights can guide the development of novel, efficient, and reversible male contraceptive methods.
  • Further research into OS-related sperm proteins is crucial for advancing reproductive medicine.